刚收到的e-mail通知..有新的研究任务推出..
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niceword.tw - You Can Help End Childhood Cancer
Alert to all members of World Community Grid - your donated computer cycle time may now help find a cure for childhood cancers! There is a group of cancers that are particularly loathsome because they normally only strike young children. Neuroblastoma is one of these cancers, arising in children under the age of two and resulting in a less than 40% survival rate.
While scientists have uncovered the three proteins that enable this cancer to grow, they now need to search the three million drug candidates for a treatment. And your computer can help us complete this search in the next year.
If you are currently contributing and want to check to see if you are contributing to this project, click here. If you are no longer contributing but would like to contribute to this project, please click here.
The cause of neuroblastoma is unknown, but most physicians believe that it is an accidental cell growth that occurs during normal development of the sympathetic ganglia and adrenal glands. It occurs most often during the first two years of a child's life, and has a high risk for disease relapse with survival rates of less than 40 percent.
The rapid advancement of genetic research at Chiba Cancer Center Research Institute holds great promise for treating neuroblastoma. The new Help Fight Childhood Cancer project will use the idle computational power from your computer to identify which of the three million potential drug candidates can inhibit growth of three particular proteins believed to prevent successful treatment via conventional approaches, such as chemotherapy.
"Our promising research will be further advanced by the free computing power we will use from World Community Grid," said Dr. Akira Nakagawara, the principal investigator at the Chiba Cancer Center Research Institute. "It would take us about 100 years using our own computing resources to make progress, but with access to one of the world's largest virtual supercomputers, we estimate to complete this project in two years, and begin laboratory trials."
Dr. Nakagawara recently earned the Princess Takamatsu Cancer Research Fund Prize 2008 for his neuroblastoma research. In his work, he discovered that one protein, TrkB, is expressed at high levels in aggressive neuroblastomas and enhances the tumor cell's growth. World Community Grid will conduct complex chemistry simulations to determine which drug candidates bond to TrkB, as well as the proteins ALK and SCxx, so that those can be tested further in the laboratory. All results will be made available to the general scientific community to advance the field of cancer biology and drug discovery.
For more information about the Help Fight Childhood Cancer Project and other projects running on World Community Grid, please click here.
We sincerely appreciate your wonderful support!
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Google翻译如下:
niceword.tw -您可以帮助结束儿童癌症
提醒所有成员全球社区网格-您捐赠的计算机周期时间现在可能有助于找到治疗癌症的童年！有一群癌症特别可恶，因为它们通常只罢工年幼的子女。神经母细胞瘤是一种癌症，中产生岁以下的儿童，并造成两名不到40 ％的存活率。
虽然科学家已经发现了三种蛋白质，使这种癌症的增长，他们现在需要搜索3000000候选药物进行治疗。和您的计算机可以帮助我们完成这个搜索在明年。
如果您正在作出贡献，并希望检查，看看您是否是促成这一项目，请点击这里。如果您不再贡献，但希望有助于这一项目，请点击这里。
神经母细胞瘤的原因尚不清楚，但多数医生认为，这是一个偶然发生的细胞生长在正常发展的交感神经节和肾上腺。它通常发生在头两年的孩子的生命，并有一个高风险的疾病复发与生存率不到百分之四十。
一日千里的发展基因研究在千叶县癌症中心研究所拥有大有希望治疗神经母细胞瘤。新的协助打击儿童癌症项目将利用闲置的计算能力从您的计算机，以确定其中的300万潜在候选药物能够抑制经济增长的三个特定蛋白质认为成功的治疗，以防止通过传统方法，如化疗。
“我们有希望的研究将进一步得到先进的计算能力，自由，我们将使用来自全球社区网格说： ”晃Nakagawara的首席研究员在千叶县癌症中心研究所。 “这将使我们大约100年使用我们自己的计算资源方面取得进展，但获得一个世界上最大的虚拟超级计算机，我们估计，完成该项目在两年内，开始实验室进行试验。 ”
Nakagawara博士最近获得了公主高松癌症研究基金奖2008年，他的神经母细胞瘤的研究。在他的工作，他发现一种蛋白质，受体，表示在高水平的侵略性神经母细胞瘤和增强肿瘤细胞的生长。全球社区网格将进行复杂的化学模拟，以确定哪些药物候选键受体以及蛋白碱和SCxx ，从而使这些测试可以进一步在实验室。所有的结果将提供给广大科学界推进领域的癌症生物学和药物发现。
如需了解更多关于协助打击儿童癌症项目和其他项目上运行的全球社区网格，请点击这里。
我们真诚地感谢您精彩的支持！
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把此任务加入运算任务请点:
http://www.worldcommunitygrid.org/ms/viewMyProjects.do?utm_s...&utm_campaign=hfcc_announce加入方法
